As a frequent coupon user I know of no national retail stores that will accept register rewards from Walgreen's. Wal-Mart accepts other stores coupons but not for dollar amounts off the entire order which is what register rewards are. I also have learned that Walgreen's register rewards have many restrictions and to me they are just not worth it anymore. I can take most Walgreen's coupons or sale prices and use them at Wal-mart.
I work at Walgreens, and basically if u get Walgreens register rewards, you're supposed to use them at Walgreens, and if u use them at a different store it will be called coupon fraud, and if u get caught u can get into some serious problems, we have seen it happen