I do not think it is possible to lose a pound in five minutes. You can run at a rate of 10 miles per hour to burn a high calorie rate between 30 to 60 minutes. This means that the pace of running for every mile will be 5 minutes for one hour. For example, a person weighing 190 lbs would is able to burn about 1550 calories running at this pace for 1 hour. He or she will lose more that 1/2 lb. of weight from burning the calories.