The cause of death is not known, but some scholars believe that he was sick for over a month before he died. On March 25 1616, Shakespeare signed his dictated will with a shaky signature, evidence of his frailty at the time. Also, it was customary in the early seventeenth century to draw up your will on your deathbed, so Shakespeare must have been acutely aware that his life was coming to an end.
The cause of William Shakespeare's death is unknown. He died on April 23, 1616. Some say that a serious outbreak of typhus, known as the "new fever" was the cause of his death. But there is good cause to believe that Shakespeare was ill for some time prior to his death.