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Which actors are best known for playing "nut cases" in their films?

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Some of the best known for playing "nut cases" in their films include Johnny Depp, Brad Pitt, Jack Nicholson, James Cagney, Anthony Hopkins and Jim Carrey among others. They usually play the roles of Villains, Evil Wizards, Thugs, Nut Cases and entirely Meanie. Check out http://www.imdb.com/list/wSSLi3pH5vA/ for more information.

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Good call. I forgot about Jack Nicholson. "One Flew Over the Cuckoo's Nest" and "The Shining". Two unbelievable Nicholson performances.
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Christopher Lloyd comes to mind. He played a mental patient in "One Flew Over the Cuckoo's Nest", burned-out ex-hippie Jim Ignatowski on the sitcom "Taxi", and the loveably bizarre Doc Brown in "Back to the Future".

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Great answer!

I loved him on Taxi!

"What's the yellow light mean?"

"Slow down."

"Whaaaat doesss the yelloooow liiight meeeean?"

haha
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And Doc Brown!

"Ok 'Future Boy', whose President of the United States in 1985? ... RONALD REAGAN?! The ACTOR? And who's VICE President, JERRY LEWIS?!"
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That whole yellow light scene in Taxi was ad-libbed. Probably the most memorable moment on the show and it was never scripted. Christopher LLoyd was amazing. So were De Vito and Andy Kauffman.
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Jgirl123

...Chris Farley,Dennis Hopper, Jerry Lewis,Lucille Ball, Groucho Marx...and the Marx Brothers.The Three Stooges.

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Goofballs and nut cases are different things. The only person in this list who played a serious nut case was Dennis Hopper.
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Jgirl123
...Tell That one to The "Shrinks". Why? because Nut Cases Do Goofy Things.Have you Ever Worked Around or In a Mental Facility? I Have.The Nut Cases Dance to No Music,catch Imaginary Birds, Tear their Clothes off and Run Outside,Capering across the grass like De-ranged Monkeys,Cackeling Madly and Yelling "Here I am! start my Garden Party...I've got the Baloons! " Then they turn Hand-springs on the grass.I Tell you...If these Nut Cases Aren't Acting Goofy..I'll Eat my favorite Handicapping Hat.Westie.
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Kathy Bates, Anthony Hopkins.

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rshackleford

That freak who was in the remake of "Ben". He was the dad in back to the future. He was on letterman and freaked out and almost kicked Dave in the head. Dave cut to commercial and threw the guy out. He was gone when the commercial was over. Think the clip is on YouTube.

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Crispin Glover? He doesn't Judy PLAY nutjobs, he IS a nutjob!
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Crispin Glover is the man!! Especially in Back to The Future..I love that role!!
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"last night Darth Vader came down from Mars and told me he would melt my brains if I didn't ask Lorraine to the dance !!"
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^ Shack is referring to Crispin Glover.

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Jack Nicholson is the first one that come to mind. He was great at playing crazies. The Shining.
Anthony Hopkins - Silence of the Lambs
Anthony Perkins - Psycho

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Gary busey

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