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Can someone tell me if taking Methatrexate or "chemo" can change
effect your taste & smell?

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Yes it can and this is usually due to discomfort in the mouth or tiny ulcers in the inside parts of your cheeks, throat or tongue. You can reduce this by taking plenty of fluids and good mouth care using a tender brush. You can find more from this link http://medicineworld.org/cancer/breast/treatment/chemodrugs/methotrexate.html.

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