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Which would stop Hardy-Weinberg equilibrium from happening?

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The theory of Hardy-Weinberg Equilibrium in genetics only works in a perfect setting. Several factors can throw off the Hardy-Weinberg theory such as random mating and mutations due to environmental influence. For more information on the Hardy-Weinberg Equilibrium theory see: http://www.uic.edu/classes/bms/bms655/lesson13.html.

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