The key lies in petting the guinea pig. Like all pets, it craves petting and contact. However, learn to read its different sounds for problems. If it purrs, it is experiencing pleasure in your petting. You need to ease into petting first, for he has to trust you first. Treats also work fine. The best treats are baby carrots. For more details, visit http://www.ehow.com/how_4549221_make-guinea-pig-less-anxious.html.