depends if they are venomous and if you are afraid. If they are non-venomous and you know some one who likes snakes, ask them to catch them and relocate them at least 30 minutes away from your house. if they are venomous i would highly suggest calling some one.
If you have a lot of snakes in your home, there may be a snake den living under your house. These dens go very deep and they're impossible to get rid of. You also could have a snake den NEAR your home, which is also hard to get rid of. If you're renting, move. If your home is bought...I don't know- well known exterminators ?