Most weight loss drugs are a rip off, but there are a few that can help a little. Raspberry Ketones helped expidite my weight loss. They will only help if you really are dieting and exercising. They're not meant to lose the weight for you, just help if you're already doing all you can. Also, I've heard good things about Alli.
Some of the vitamins and supplements that have been proven to help people lose weight include; Calcium, Conjugated linoleic acid (CLA), green tea extract, meal replacements, and an over-the-counter weight loss drug known as Orlistat. You should realize that supplements and vitamins alone won't make you lose weight; diet and exercise are by far the best methods. Talk to your doctor before you start on any supplement or vitamins.