Hospice is always good. I worked for a Hospice in my area years ago and the money that was raised was actually used to help the local people that actually needed it. Also your local food bank is a good idea , there are always hungry people.
What charities "speak" to you? What seems most important to you? My two favorite causes are Breast Cancer research, as I'm a 2X survivor, and also, Boys & Girls Clubs, because it has always seemed to me that our young people are our most precious resource. And it's always seemed to me that there's something very WRONG about spending millions to build prisons, yet next-to-nothing to support those same precious young people! At least, that's my take on it!