I play with the jokers, so if ur playin teams (4 people,with jokers. U take out the 2 of hearts and 2 of diamonds. If ur playing cut throat (3 people) u rake out the 3 of clubs, u can also play with 4 people everyone for them self, board is 3 wheels is 7 :)
It depends on when you are talking about taking a card out. In Spades you do not play with the joker cards so you would take those out of the deck before you play. All other cards can be used during game play.