Most depression medication do not interfere with over the counter medication. However there are some exceptions to the rule. It is always best to consult your pharmacist or doctor before taking anything. In a prescription there is always information about the side effects and what things could cause a reaction.. It is advisable to always read to help avoid complications that may arise. As far as Buspar and Aleve being incompatible, there is no evidence that says they cannot be taken together. As always consult your doctor or pharmacist for any concerns.