Take your hamburger meat and mix it with an egg, (some) bread crumbs, and whatever herbs/spices you desire. After that roll each into a ball and (as I make them for spaghetti) sauté them in a pan, covering with a lid every so often, until they're cooked all the way through.
Well coming from a REAL Italian who grew up with meatballs every Sunday dinner the real Sicilian way is real bread soaked in milk added to ur beef no low fat stuff or it will be dry an hard add Parmesan cheese and garlic an salt. That simple. Pan fry with oil half filled is best but can bake in oven at 350 for 30 mins.