Combat in general, kill bosses and dragons and slayer for profit. Skills well, mining-clau, iron, and runite are good. Smithing, offhand weapons are new and seem profiting, some bars are profiting. Farming-herbs and stuff. Herblore-make unf potions, check prices some are profiting, or just cleaning herbs. Crafting-make dhide armour pieces or some of the new bat and imp robes and books which seem new and might make profit-check prices. Runecrafting nature runes makes some profit i think still.