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okay so basically, i watch Grey's Anatomy, but i started watching from season 8, and I'm also catching up, I'm in the middle of season 2 at the same time. i was reading something about the show and apparently, Dr. Alex Karev married Dr. Izzie Stevens in season 5 or 6 or something. these are seasons that i didn't see yet. but in the later seasons, like 8 and 9, Izzie NEVER shows up in the show, and Dr. Alex Karev hits on other doctors... what happened with him and Izzie? (sorry, I'm really curious to know what happened)

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It gets SUPER complicated in that little mix. Basically, (SPOILER ALERT):

Izzie gets cancer, and has to take time off from being a surgeon. In the merger between Seattle Grace and Mercy West, there's tension over who will get to keep their jobs or not. When Izzie gets upset at one of the new residents, she accidentally medicates a patient incorrectly and renders the patient unable to get a transplant she's needed for years.

That was the tipping point, and when Izzie found out Alex had a hand in talking to Chief Webber, she got really angry and literally walked away from him, leaving only a note behind. She makes the odd appearance again but not as a surgeon, and you don't see her again after the end of season 6.

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