Well to zip in and out of tight places as you escape from the police, a motorcycle. For a long trip on a rainy night, a car. A motorcycle, you have to hold on and get vibrated continuously. A car is more cushy, you can sit back and relax.
I find cycles more exhausting, mentally and physically. I always worry more about other drivers and road conditions, plus i hate the balancing when you have to stop. In a car I can do 80 and its like nothing, on a bike doing 60 on highway is nerve wracking. but damn its fun