Most garage door openers have rolling codes. Once your remote loses connection it has to relearn the codes. Have you pressed the "learn button" on the back of the overhead unit before holding down the button on the remote so it can relearn?
You need to check the inputs on any panel to ensure that the opener re-learns any wireless control modules. Replacing the bulbs in the unit might also help to see that the light turn on. If this does not work, you may also replace the door opener. Get in touch with a technician.