I know most people probably aren't looking at this post but yes it is possible. Download an emulator for an android phone, then download the game from google play and install it on the emulator. The emulator works as if you have a real phone and you can just click instead of using the touch screen. To find and emulator type "android phone emulator" into google or your prefered search engine. Enjoy!!
You cannot play 4 pics 1 word on your computer. The game is optimized for mobile phones, both android and iOS phones. You can download it from your Apple store for free as long as your device meets the requirements.