Do not under any curcumstances take it with depressiin/anti-anxiety meds at the same time. You CAN overdose!!! One or the other but not both. St. Johns Wort is great for mild depression but may not work for deep, clinical depression or manic-depression. If you take Wort make sure your doctor kniws and follow his directions. Self medicating something as serious as depression can be is never good.
St. John's Wort is a herbal remedy used presently to treat a condition like depression and other similar ones like anxiety, loss of appetite and tiredness. The drug can take as long as 2 weeks or more before starting to have any effect on your mood. The most common side effect is insomnia, which is more likely to be worse on higher doses. Read more on http://www.choiceandmedication.org/nsft/medications/105/.