The universal theme of Despicable Me is: "Don't allow others to determine your limitations". Gru - everyone said he was just an evil villian, even his own mother. But then he adopted the 3 girls. The girls - the orphanage said they'd never find homes, and they did. The minions - they're just genetically-engineered corn pops who are basically just servants, even slaves, to Gru. But they ended up being the best part of the movie. Never let anyone tell you who you are or what you can or can't do!