Like Tylenol PM..? Sure, as long as you're not on any medications you're not supposed to take something like that with. All that'll happen is you might get a little sleepy. The ingredient in Tylenol PM for sleep is the same as in Benadryl, the allergy medication. Some people take it w/o sleepy effects during the day, but if you're not used to it, you may feel tired. Plus, if you're like me & your cramps are severe, take it, then take a nap! I have endometriosis & get excruciating cramps, so a nap isn't a bad thing at all. If you don't want to sleep, take it with coffee or something like Coke that has caffeine in it. Caffeine helps pain meds to work better & will help counteract the sleepy effect. Feel better!