I'm not sure if this is what you're asking, but Atherosclerosis is a chronic, progressive disease in which plaques (consisting of deposits of cholesterol and other lipids, calcium, and large inflammatory cells called macrophages) build up in the walls of the arteries.These plaques can cause several problems. First, plaques can protrude into the artery, eventually causing a partial or complete obstruction to blood flow. Second, plaques can suddenly rupture, causing a blood clot (thrombus) to form, leading to sudden occlusion of the artery. (This condition is called arterial thrombosis.) Third, plaques can weaken the wall of the artery causing a ballooning out of the artery to form what is called an aneurysm. The rupturing of an aneuyrsm often produces severe internal bleeding.