Is there always something wrong with you when your friends look at you funny?
No, of course not. They're probably looking at you funny because you might be different than them. Popular people do that. There is something wrong with them if look down upon you.
no if anything they are hatein'
Not necessarily. It could mean you just did something really weird or stupid. Which means that there was something wrong with what you did, not you as a whole.
Not on April Fool's Day. Or are they looking funny because of something someone else did on April Fool's Day. In other words they are pranking you, or someone else has.