According to their site, Active ingredient (in each 5 mL = 1 teaspoonful) Diphenhydramine HCl 12.5 mgPurposeAntihistamine
So 2 tsp would be very close. I give my dogs Benadryl and I found it easier to get the adult tablets. One tablet is the same dose as two tsp. of the children's . I find it easier to put the tablet in a piece of cheese and be done.