I have a 1998 Mustang that I drove off the lot brand new. I had some do a bad maintenance fluid change in my rear axle that cost me, but other than that, I haven't had any issues. My husband has 2002 Explorer Sport. The clutch went out, twice, but that is because he rides it. (his next vehicle will be an automatic)
As long as you maintain them IMO they will last a long time.
Yes. My brother has a 20 year old Ford and it still runs like a dream. The only issues we've had was the battery ran out 6 times (because my brother was irresponsible and left the lights on) and the truck is 20 years old.