Nope, you can't get sick from them. They can just be pesky and hard to get rid of. The bites are annoying, im sure. My sister bought a brand new mattress from Rentquick 5 months ago. They sell used mattresses as well, and store both new and old together. These little bites started appearing all over she and her husband. After about a month or so, they discovered the little bugs. Somebody had brought a used mattress infested with them, and in turn, infested the entire store. It took my sister 3 months to finally get rid of them all.