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How to prepare 5-Hydroxymethylthiazole, I want an easy way to prepare it.

5-Hydroxymethylthiazole is an important intermediate for Ritonavir, and a kind of anti-AIDS pharmaceuticals. How to prepare 5Hydroxymethylthiazole, I want an easy way to prepare it.

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Actually, you mistake us for people who can even pronounce "Hydroxymethylthiazole". If you can find someone on here who even knows the difference between "their", "there", and "they're", then you've probably encountered one of the top ten intellectuals on this site.

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Lmao!!! :)
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you mistake us for chemists.

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Here is a very simple way to prepare this chemical, I hope it helpful for you!!

In a reaction flask IOml 50ml of methanol, 1. 5g (IOmmol) 2_ chloro-5 - (hydroxymethyl) thiazole and 1. 7g (26mmol) of zinc powder, the above mixture was heated to 50 C, and hydrochloric acid was slowly added 30ml (IN), at a temperature of 60 C for 2 hours detected by TLC or HPLC, until the starting material disappeared, the reaction was stopped and the reaction solution was filtered, concentrated and neutralized with sodium hydroxide to PH is 9, then extracted with ethyl acetate to give crude product, the final crude solvent was removed by distillation under reduced pressure, collecting 115 ~ 122 C (24mmHg) the distillate, 1.05g 5 - (hydroxymethyl) thiazole(Reference: http://www.guidechem.com/cas-385/38585-74-9.html). The determination of the purity of 94%, the yield was 85%.

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