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How should this be punctuated

pharmaceautical companies are faced nevertheless with unusually expensive research and development costs.

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"nevertheless" is parenthetical and should be separated from the rest of the sentence by commas:

pharmaceutical companies are faced, nevertheless, with unusually expensive research and development costs.

Stylistically speaking, I think it reads a little more smoothly if you move "nevertheless" further forward:

Pharmaceutical companies are nevertheless faced with unusually expensive research and development costs.

That way, it's no longer parenthetical, you don't need the commas, and it doesn't disrupt the flow of the sentence.

Or, as other posters have suggested, open with Nevertheless:
"Nevertheless, pharmaceutical companies..."

Any of these are technically correct, it's just a question of what reads most smoothly.

Hope this helps!

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thanks boo.
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Nevertheless, pharmaceutical etc...

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Nevertheless, pharmaceutical companies are faced with unusually expensive research and development costs.

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That_0ne_Guy

Nevertheless, pharm. etc.

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Pharmaceutical (no a) companies are faced, nevertheless, with unusually expensive research and development(al) costs.

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Briando

A few things including capitalization, and spelling. See below.

Pharmaceutical companies, nevertheless are faced with unusually expensive research and development costs.

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