To sneak past the science labs on the game, you have to obtain the Laser Prototype in the Vault. After hiding from the sac in the black box a short movie will come on. You have to kill the 2 thugs/doctors working on the patient after the movie is over. Then deactivate the laser after the kill and unlock the straps pinning Jacobs on the board using the lock pins. You can go to faqs.ign.com for more tips on the game tactics.