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Why do generally happy kids get depressed when they start using drugs?

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It's the effect of the drugs on the brain.

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It messes with the brain.

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The drugs will act as an inhibitor when the body releases endorphins to the brain. Also, many people take drugs because theyre depressed, so its often a two way streak

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Just my opinion but I don't think kids would start taking drugs if they're genuinely happy, drugs are normally started just to fit in with friends and regardless of what your 'cool' friends say your gonna be battling your conscious. If your desperate enough to ignore your conscious to fit in your not happy with your current situation and your gonna be depressed. It just gets worse or more visible to others after a while because drugs and druggy friends won't make you any happier.

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Well, with crack cocaine its high makes your levels of dopamine increase, making you feel happy. However, the levels of dopamine suddenly decrease and you end up feeling depressed which is why people using this drug become addicted just for that 10 minutes of happy.
Here's where i got it from: https://www.youtube.com/watch?v=vxI7PTVRfhQ&feature=c4-overview&list=UUC552Sd-3nyi_tk2BudLUzA

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Some drugs change the levels and amount of "Serotonin", which is a monoamine neurotransmitter and natural substance developed in the brain

http://en.wikipedia.org/wiki/Serotonin#In_the_brain

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