It can stay in your body for 2 to 3 days or so. Lisinopril is an angiotensin converting enzyme inhibitor. Angiotensin is a chemical that is made by the body continuously. It narrows blood vessels and thereby maintains or elevates blood pressure. When the enzyme is blocked by lisinopril, angiotensin cannot be converted into its active form. As a result, blood pressure falls.
Lisinopril's half-life is reportedly 12 hours. This means that the drug should be present in your body for around 3-4 days. But this doesn't mean the side effects are also limited to the same number of days since some of the side effects of this drug may take at most 2 weeks to disappear completely.