Yes, it can interfere with antibiotics. It may either weaken the effects of the antibiotics or it may react with the drug more harmfully causing several adverse reactions to occur. Keep in mind that if you combine these two, the effects will surely differ from one person to another. For more information check this site: http://www.mayoclinic.com/health/antibiotics-and-alcohol/AN01802
In general, alcohol is contraindicated once a person is taking medications including antibiotics. Alcohol contains chemicals and elements that otherwise interfere with the absorption, digestion, metabolism, and excretion of antibiotic hence making antibiotic ineffective.
Alcohol competes for the metabolic site of antibiotics thus reducing their effectiveness and increasing their side effects. Hence it’s recommended not to drink alcohol with medicines. For detailed information visit http://www.netdoctor.co.uk/ate/infections/203424.html