The first psychotropic drugs were alcohol, opium, psilocybin mushrooms, belladonna alkaloids, and a lot more. They were first found in nature just before people learned to manufacture them in laboratories. Lithium was considered to be the first psychotropic drug made in medical laboratories.
Lithium is the first psychotropic drug. Lithium the simplest alkali metal, the lightest solid element, and the third lightest chemical element with an atomic number of 3; Lithium carbonate or other preparations of lithium metal used to treat manic depression and bipolar disorders.
Lithium was the very first psychotropic drug that was made and tested. It is primarily used to stabilize the mood in bipolar patients. It can be used in both acute and long term treatment. For more information, follow this link: http://www.ask.com/wiki/Lithium_(medication)