A 12-ounce serving of Pepsi contains 41 grams of sugar. The sugar and high fructose corn syrup found in Pepsi are responsible for the 150 calories delivered by each 12-ounce serving. A 20-ounce bottle of Pepsi contains 69 grams of sugar and 250 calories.
The same 12-ounce serving of Diet Pepsi does not contain any calories or sugar, but it does deliver a full 35 grams of sodium. The American Heart Association recommends limiting the consumption of calories from sugar to no more than 100 per day for women and 150 per day for men to minimize the risk of weight gain leading to obesity and diseases such as metabolic syndrome and diabetes.