The British Journal of Clinical Pharmacology reports that prednisolone is a synthetic drug that is also the active metabolite of prednisone, another synthetic drug. Prednisolone is a glucocorticoid that’s primarily used to treat auto-immune and inflammatory conditions, especially in patients with liver disease who are unable to convert prednisone into prednisolone. Prednisone is a corticosteroid that is most often used as an immunosuppressant drug.Know More
Prednisolone has a low level of mineralocorticoid activity, according to Clinical Pharmacokinetics. This property makes prednisolone effective for treating common conditions such as asthma, cluster headaches, rheumatoid arthritis and Crohn’s disease. Physicians also use prednisolone for other inflammatory conditions, such as Bell’s palsy, pericarditis, multiple sclerosis and ulcerative colitis. Rare conditions that may be treated with prednisolone include pyoderma gangrenosum, temporal arteritis and uveitis.
Physicians most often use low doses of prednisone to treat allergic reactions and higher doses to treat some forms of cancer. Prednisone is also a common treatment for laryngitis, myasthenia gravis, rheumaticdisorders, thyroiditis and tuberculosis. Drugs.com reports that prednisone is an effective part of a regimen for preventing tissue rejection after organ transplants. Prednisone's effectiveness as an immunosuppressant also means that susceptibility to infections is a significant side effect of this drug.Learn more about Medications & Vitamins
Benzoylecgonine, also known as ecgonine benzoate, is the main metabolite of cocaine. Produced by hydrolysis, benzoylecgonine can be detected in urine for a minimum of 5 days after usage of cocaine. Heavy usage can lead to detection up to a month after usage, and it can take heavy users up to four months to clean out their system completely.Full Answer >
A prednisone tapering schedule can be employed by taking a smaller dose of prednisone over a period of time until you finish the medication. It is important to talk to your medical provider before employing the tapering method.Full Answer >
The mechanism of action of prednisone in polymyalgia rheumatica is not well understood, and many believe the efficacy of treatment is related to the anti-inflammatory and immunomodulatory effects of the drug, explains Medscape. Polymyalgia rheumatic responds to low doses of prednisone, and some patients require treatment for several years.Full Answer >
Weight gain is normal when taking prednisone due to the drug's potential for causing salt retention, water retention and increased hunger. Prednisone weight gain can be combated by changing one's diet, exercising, and reducing the dosage taken, according to gihealth.com.Full Answer >