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What is MCHC?

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Mean corpuscular hemoglobin concentration, or MCHC, is one of three indices referenced in the red blood cell portion of complete blood count panel, according to Medscape. Abnormal MCHC results indicate certain types of anemia. Normal adult MCHC levels are 33 to 36 grams per deciliter.

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MCHC is calculated by comparing the hemoglobin mass in red bloods with the fraction of whole blood composed of red blood cells, explains Medscape. As such, laboratories use MCHC results mainly as a control to ensure accuracy of the other indices. When MCHC numbers are elevated and the results are accurate, it usually points toward hereditary spherocytosis. In rarer cases, increased MCHC numbers can indicate homozygous sickle cell anemia or hemoglobin C disease.

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