A necrotic tumor is a tumor that has one or more areas of dead tissue, usually related to growth beyond the tumor's blood supply, says the Free Dictionary. Some researchers believe portions of tumors turn necrotic when they're deprived of oxygen, notes Japanese Journal of Clinical Oncology.
Necrosis refers to the death of cells, and until recently, it was thought to be an unregulated occurrence during which the cell membrane is destroyed, says National Center for Biotechnology Information. New data shows that it may actually be a well-regulated process activated by particular stimuli. Unlike another type of cell death called apoptosis, necrosis usually causes inflammation that may be involved in tumor regression in patients undergoing anticancer therapy. However, when a tumor is developing, excessive necrosis results in more aggressive tumors because the inflammation caused by necrosis can stimulate their growth.
Carcinoma patients with some types of tumor necrosis are more likely to experience less favorable outcomes, including recurrence of disease, explains Japanese Journal of Clinical Oncology. In a study of patients with urinary tract carcinomas, researchers found that necrosis tended to be more common in larger tumors. The presence of necrosis in a tumor may provide doctors with a tool for predicting how aggressively the tumor is growing.Learn More
Most side effects of radiation therapy will subside shortly after the treatment is ended, but some side effects can be permanent and others can come months or years after the radiation therapy is ended, according to WebMD.Full Answer >
Mutations in JAK2 are primarily associated with three diseases: essential thrombocythemia, polycythemia vera and primary myelofibrosis, according to Genetics Home Reference, a service of the National Institutes of Health. These diseases are all caused by misregulated cell production; JAK2 is a protein that regulates cell growth and proliferation.Full Answer >
A complete blood count, also called a CBC, can detect some blood cancers based on the amount of certain blood cells in the blood, according to Mayo Clinic. Abnormal blood cells can also be a sign of cancer. A bone marrow test confirms a diagnosis of blood cancer.Full Answer >
Signs of kidney cancer include bloody urine, unexplained low back pain on one side, unexplained weight loss, or a lump on the side or lower back, states the American Cancer Society. Other symptoms are tiredness, appetite loss, unexplained prolonged fever and anemia. However, all of these usually have noncancerous causes.Full Answer >