According to Dr. Lam, studies have shown that certain combinations of amino acids, such as secretagogues, can stimulate the pituitary gland to secrete human growth hormone or hGH. Some clinical trial results have been positive. Therefore, if Secretagogue One is based on the same science, it could potentially work.
In the Supplement Critic, Derek Peterson says that Secretagogue One contains 5 grams of a mixture of eight different amino acids. He points out that similar products contain at least 5 grams of glutamine and usually contain colostrum, as well. He suggests that Secretagogue One may not contain the most effective formulation possible. However, he also confirms that many consumers have reported excellent results from the use of Secretagogue One.