The drying time of silicone or acrylic latex caulk varies depending upon the specific brand and type, but, in general, it dries enough to be exposed to water or paint in 2 to 12 hours. Caulk is usually completely cured in 24 hours.
Temperature and humidity level makes a difference in the curing time of caulk. Cooler temperatures and lower humidity increase the time required. Under these conditions, 48 hours is often necessary. Caulks come in a variety of types. Some are waterproof, such as for windows, doors and baths. Paintable caulks are appropriate for interior molding and baseboards. A caulk that has both qualities is useful when an area is exposed to water or the outdoors and a particular color is desired.