Q:

How long does it take for Benadryl to make a dog sleepy?

A:

Quick Answer

A dog becomes sleepy within 60 minutes from administration of a properly sized dose of Benadryl, according to AZVets.com. Peak levels of the active ingredient diphenhydramine are found in blood circulation within one to five hours, as noted in The Merck Veterinary Manual.

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Full Answer

Proper dosage of Benadryl is 2 to 4 milligrams per kilogram of pet weight, as prescribed by The Merck Veterinary Manual. This agrees with the simple rule of 1 milligram per pound recommended by AZVets.com and DoseMyPet.com. As an example, a 30-pound dog should be administered 30 milligrams of Benadryl in a proper dosage.

Some over-the-counter products containing Benadryl also contain other medications that are toxic to canines, including acetaminophen or pseudoephedrine. AZVets.com recommends checking labels closely and obtaining the advice of a veterinarian before administering any drug to a dog.

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    Common side effects of Benadryl in canines include the presence of dry mouth, a loss or decrease in appetite with or without vomiting, diarrhea and a decrease in urine according to PedMD. Benadryl has been known to react with other prescription medications like amitraz, furazolidon and epinephrine. Special precautions must be taken when administering Benadryl, especially to pregnant canines and canines with heart diseases or high blood pressure.

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    Is it safe to give cats benadryl?

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    It is safe to give cats Benadryl as long it is administered in a safe dose, according to Pet MD. However, Benadryl works best as a preventive medicine for cats with asthma or other environmental health problems. Benadryl is commonly given to cats for problems such as allergies, increased serotonin production and appetite loss.

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    An oral dose of Benadryl reaches peak blood concentrations 2 to 3 hours after consumption, and the effects usually last for 4 to 6 hours, reports the National Highway Traffic Safety Administration. WebMD suggests taking an oral dose of Bendryal about 30 minutes before bedtime, if the drug is being used as a sleep aid, or right before traveling overseas, if the drug is being used for motion-sickness.

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