How Does Paracetamol Work in the Body?

Answer

Paracetamol is generally considered to be a weak inhibitor of the enzyme cyclooxygenase-2 (COX-2). This enzyme is important in the synthesis of prostaglandins (PG), so by inhibiting the action of COX-2, paracetamol causes a decrease in PG production. Prostaglandins are important mediators of inflammation, and their release has many effects including the sensitisation of nerve cells to pain, and a direct effect on the hypothalamus in the brain resulting in fever.
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