There are several ways to cook boneless chicken breast. It can be fried on top of the stove, baked in the oven, or even put on the grill. One of the simplest ways to cook boneless chicken is by putting it in the oven. Set the temperature to 350 degrees and cook for about a half hour. If the chicken is frozen, it will have to be cooked longer, close to an hour. Whichever method is being used, it is important to cut into the chicken and ensure that it is a nice white color and no pink remains.