Vicodin, a powerful pain medication made with acetaminophen and a synthetic opiate, hydrocodone, has a high that lasts anywhere from one to five hours, according to About.com. Vicodin is available through prescription only, and it is imperative for users to exercise caution when taking this medication.
The high feeling that users report after taking Vicodin varies depending on several factors. The high lasts longer when the drug is first ingested. One of the reasons that powerful opiates, like Vicodin, are so dangerous is that the body quickly builds up a tolerance to these drugs. The higher a person’s tolerance is, the shorter the high and the more medication that is required to eliminate pain. About.com warns that a physical or emotional dependence can develop if the medication is used for an extended period of time. Users should follow all dosing instructions and any additional instructions by the doctor or pharmacist.