Oxycodone, one of the drugs in Percocet, can be detected in a blood test for approximately 24 hours after it is taken, according to About.com. The other drug in Percocet is acetaminophen, a less potent non-opioid found in over-the-counter medications such as Tylenol.
Percocet is prescribed when a patient has moderate to severe pain, according to Drugs.com. Persons who have recently used alcohol, other narcotics, sedatives or tranquilizers should not take Percocet. The medication is addictive and should never be shared with individuals who have drug abuse or addiction histories. Percocet overdose can be fatal. The drug should only be taken as prescribed.