(Public Relations Team, Clickbooth)
We've managed to use Twitter to build some very strong relationships (the majority of our partners use Twitter to share their own blogs and info - so it has been an amazing business tool). Of course, the key is finding a nice balance between listening to and engaging followers with relevant and interesting content.
It really amazes me how many people attempt to use bots (and I love that way you phrased it). A successful salesman returns phone calls, listens to his/her customers, and doesn't allow the answering machine to do the talking. I have seen a number of these bots pop up, and the best way to manage them is to click on Twitter's feature 'report for spam' which appears right underneath the individual's account info on the right hand toolbar.
Twitter recently announced that it has drastically reduced it's spam to 1% on its blog recently. I'm not too sure how accurate that is - however, if we all step in to control it, I'm sure will see great improvements in the near future.