Tingling, "pins and needles" or any creeping feeling in the knee is called knee paresthesia, according to Right Diagnosis. This could indicate a nerve injury or a nerve disease.
Causes of the tingling include but are not limited to diabetes, peripheral artery disease, a cold, a knee injury or peripheral neuropathy. Similar symptoms in other areas of the body could be an indicator of multiple sclerosis.
Runners also may experience knee pain, which falls into one of two categories: iliotibial band syndrome on the side of the knee or patellofemoral pain syndrome around the kneecap, according to SaveYourself.ca. With either type, the runner should contact a doctor for assistance in preventing serious injury.