According to Health Research Funding, the most significant difference between Enfamil and Similac is the amount of carbohydrates and proteins in each formula. Enfamil costs less than Similac, and many mothers also find it more convenient to pack and use.
Health Research Funding states that Enfamil has higher levels of DHA and AHA in its formula, while Similac has a much higher calcium count. Enfamil has palm oil as one of its ingredients, while Similac does not. Those dealing with gassy babies are likely to be recommended Similac, since the brand manufactures a formula specially designed to deal with gas issues.