WebMD explains that a pins-and-needles tingling sensation in the hands is sometimes caused by nerve damage. Conditions that contribute to nerve damage include diabetes, celiac disease, vitamin B12 deficiency, lupus, cancer and Lyme disease. Damaged nerves tend to behave abnormally and send mixed messages to the brain that range from numbness to severe pain.
According to the Mayo Clinic, damage or disease that effects the sensory nerves, motor nerves and autonomic nerves of the body is called peripheral neuropathy. Symptoms of peripheral neuropathy include a gradual onset of numbness and tingling in the hands and feet, skin and nail changes, sensitivity to touch, coordination issues, heat intolerance, and muscle weakness. Peripheral neuropathy affects a single nerve or multiple nerves throughout the body.
Healthline explains that numbness and tingling of the hands and feet are also caused by standing or sitting in one position for an extended period of time, sitting in a cross-legged position, nerve pressure, spine pressure, inadequate blood supply to the affected area, multiple sclerosis, stroke, and shingles. While it is common for people to experience numbness and tingling on occasion, it is important to consult a physician if the pins-and-needles sensation is accompanied by dizziness, muscle spasms, rashes or frequent urination.