Topic: Homology Modeling
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Answers to Common Questions
When did you realize that gene targeting using homologous recombi...
Well, I went to one meeting in England. A guy from Germany was talking about these things called embryonic stem cells, which I had never heard of. So I thought, "Oh my gosh, maybe we could use these cells and make genetic changes in them." ... Read More »
Source: http://www.medscape.com/viewarticle/564216_6
How To Do Homology Modeling.
Molecular Modeling for Beginners by Gale Rhodes, Univ. Southern Maine, includes an introduction to DeepView, and a superb tutorial on homology modeling (look through the left index frame for the link to Homology Modeling This is the best st... Read More »
Source: http://www.umass.edu/molvis/workshop/homolmod.htm
What is homology modeling?
Suppose you want to know the 3D structure of a target protein that has not been solved empirically by X-ray crystallography or NMR . You have only the sequence. If an empirically determined 3D structure is available for a sufficiently simil... Read More »
Source: http://www.umass.edu/molvis/workshop/homolmod.htm
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Homology Modeling
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Answers to Other Common Questions
Two proteins with a high level of sequence identity, and very similar secondary and tertiary structure (identical "folds"), will nevertheless have not exactly identical backbone conformations, even when determined under comparable condition...
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Source: http://www.umass.edu/molvis/workshop/homolmod.htm
Homology models are classified into 3 area in terms of their accuracy and reliability.
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Source: http://www.molecularsciences.org/structural_bioinformatics/questi...
Good question! In general it depends how good a model you need to make, and how much effort you are prepared to put into it. For many purposes, all you need is good sequence alignment. Be careful to look for anomalies in the results from ho...
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Source: http://pdbwiki.org/mw/index.php/PDB_FAQ
This refers to Round Robin scheduling, a method implemented in various situations that require scheduling algorithms e.g in memory management within a CPU. If for example you have 5 processes loaded in memory, RR scheduling would allocate a...
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Source: http://www.askgetanswer.com/cgi-bin/answer_view.cgi?cat=others&qu...
The main impetus for the E30 M3’s existence was Group A racing, a production-based class that demanded that each race car share its core mechanical components with a road car, of which at least 5,000 examples had to be produced. Thus, BMW M...
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Source: http://forum.bmworc.ru/showthread.php?t=5103
Does FlexOracle predict the hinge points in GPCR homology models? And has anyone done such a submission.
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Source: http://faqs.gersteinlab.org/2008/02/how-do-i-submit-homology-mode...
