Topic: Hyper IGE Syndrome
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What is hyper 1GE syndrome?
it is an autosomal inherited condition where there is very high igE. this lead to reduced IL-17 that promotes neutrophil recruitment leading to neutropenia Read More »
Source: http://wiki.answers.com/Q/What_is_hyper_1GE_syndrome
How is hyper-IgM syndrome diagnosed?
The doctor will order laboratory tests that show normal numbers of T and B cells, but high levels of IgM and very low IgG and IgA. He may question whether the family recalls other relatives who became sick in infancy. Patients may also have... Read More »
Source: http://www.cureresearch.com/artic/primary_immune_deficiency_niaid...
What causes hyper IgM syndrome?
A flawed gene (or genes) in T cells is responsible for hyper IgM syndrome. The faulty T cells do not give B cells a signal they need to switch from making IgM to IgA and IgG. Most cases of hyper-IgM syndrome are linked to the X chromosome. ... Read More »
Source: http://www.cureresearch.com/artic/primary_immune_deficiency_niaid...
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Hyper IGE Syndrome
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Patients receive injections of intravenous immunogloblulin (IVIG) every three to four weeks. For neutropenia, patients can take granulocyte colony-stimulating factor (G-CSF). Their doctor may also prescribe antibiotics to prevent the respir...
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Source: http://www.cureresearch.com/artic/primary_immune_deficiency_niaid...
Infants usually develop recurring upper and lower respiratory infections within the first year of life. Other signs of the disease include enlarged tonsils, liver, and spleen, chronic diarrhea, and an increased risk of unusual or “opportuni...
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Source: http://www.cureresearch.com/artic/primary_immune_deficiency_niaid...
Elevated serum immunoglobulin E(IgE) can be caused by allergies, infections and immune conditions including hyper IgE syndrome (HIES). HIES is a rare primary immunodeficiency disease most commonly characterized by a triad of findings, inclu...
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Source: http://www.ncbi.nlm.nih.gov/pubmed/19331717
X-linked hyper IgM syndrome is estimated to occur in 2 per million newborn boys.
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Source: http://ghr.nlm.nih.gov/condition/x-linked-hyper-igm-syndrome
X-linked hyper IgM syndrome is a condition that affects the immune system and occurs almost exclusively in males. People with this disorder have abnormal levels of proteins called antibodies or immunoglobulins. Antibodies help protect the b...
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Source: http://ghr.nlm.nih.gov/condition/x-linked-hyper-igm-syndrome
Mutations in the CD40LG gene cause X-linked hyper IgM syndrome. This gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. CD40 ligand attaches like a key ...
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Source: http://ghr.nlm.nih.gov/condition/x-linked-hyper-igm-syndrome
